发明申请
WO2005101838A3 PIPERAZINYLPIPERIDINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS
审中-公开
作为化合物受体拮抗剂的哌嗪衍生物
- 专利标题： PIPERAZINYLPIPERIDINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS
- 专利标题（中）： 作为化合物受体拮抗剂的哌嗪衍生物
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申请号： PCT/US2005012265申请日： 2005-04-12
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公开(公告)号： WO2005101838A3公开(公告)日： 2006-03-02
- 发明人: XUE CHU-BIAO , CAO GANFENG , HUANG TAISHENG , CHEN LIHUA , ZHANG KE , WANG ANLAI , MELONI DAVID , ANAND RAJAN , GLENN JOSEPH , METCALF BRIAN
- 申请人： INCYTE CORP , XUE CHU-BIAO , CAO GANFENG , HUANG TAISHENG , CHEN LIHUA , ZHANG KE , WANG ANLAI , MELONI DAVID , ANAND RAJAN , GLENN JOSEPH , METCALF BRIAN
- 专利权人： INCYTE CORP,XUE CHU-BIAO,CAO GANFENG,HUANG TAISHENG,CHEN LIHUA,ZHANG KE,WANG ANLAI,MELONI DAVID,ANAND RAJAN,GLENN JOSEPH,METCALF BRIAN
- 当前专利权人： INCYTE CORP,XUE CHU-BIAO,CAO GANFENG,HUANG TAISHENG,CHEN LIHUA,ZHANG KE,WANG ANLAI,MELONI DAVID,ANAND RAJAN,GLENN JOSEPH,METCALF BRIAN
- 优先权： US56169704 2004-04-13; US57222104 2004-05-18
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K45/06 ; C07D401/06 ; C07D401/14 ; C07D417/14 ; C07D471/04 ; A61K31/495
摘要：
The present invention relates to compounds of Formula (I): wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
公开/授权文献
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