发明申请
WO2006006948A2 METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
审中-公开
用于选择改进功能的siRNA的方法和组合物
- 专利标题： METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
- 专利标题（中）： 用于选择改进功能的siRNA的方法和组合物
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申请号： PCT/US2004/014885申请日： 2004-05-12
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公开(公告)号： WO2006006948A2公开(公告)日： 2006-01-19
- 发明人: LEAKE, Devin , REYNOLDS, Angela , KHVOROVA, Anastasia , MARSHALL, William , FEDOROV, Yuriy , READ, Steven
- 申请人： DHARMACON, INC. , LEAKE, Devin , REYNOLDS, Angela , KHVOROVA, Anastasia , MARSHALL, William , FEDOROV, Yuriy , READ, Steven
- 申请人地址： 2650 Crescent Drive, Suite 100, Lafayette, CO 80026 US
- 专利权人： DHARMACON, INC.,LEAKE, Devin,REYNOLDS, Angela,KHVOROVA, Anastasia,MARSHALL, William,FEDOROV, Yuriy,READ, Steven
- 当前专利权人： DHARMACON, INC.,LEAKE, Devin,REYNOLDS, Angela,KHVOROVA, Anastasia,MARSHALL, William,FEDOROV, Yuriy,READ, Steven
- 当前专利权人地址： 2650 Crescent Drive, Suite 100, Lafayette, CO 80026 US
- 代理机构： KALOW, David et al.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G06F19/00 ; G01N33/48 ; G01N33/50 ; C07H21/02 ; C12N15/87
摘要：
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
