A system for generating a bioactive dosage form, including a first drop-on-demand fluid ejector (126) fluidically coupled to a first reservoir (118) that contains a first fluid having a first reactant. The first drop-on-demand fluid ejector is capable of ejecting a drop (146) of the first fluid onto a pre-selected location of an ingestible substrate (310). In addition, the system also includes a second drop-on-demand fluid ejector fluidically coupled to a second reservoir that contains a second fluid having a co-reactant which reacts with the first reactant. Either the first fluid or second fluid contains a bioactive agent.