The invention relates to novel genes from lysolipin-producing microorganisms, to novel gene clusters formed from novel and/or known genes of these microorganisms, to expression products of these genes, to a transformation vehicle containing these genes, gene fragments or gene clusters, to transformed cells containing these genes or gene clusters, to methods for the biotechnological production of lysolipin derivatives, to methods for the combinatory biosynthesis of lysolipin derivatives, to novel lysolipin derivatives, to uses of these lysolipin derivatives, and to pharmaceutical compositions containing these lysolipin derivatives.