Invention Application
WO2006039806A1 DEPRESSION OF HERG K+ CHANNEL FUNCTION IN MAMMALIAN CELLS AND APPLICATIONS TO THE CONTROL OF CANCER CELLS DIVISION
审中-公开
在哺乳动物细胞中抑制HERG K +通道功能和应用于癌细胞分裂的控制
- Patent Title: DEPRESSION OF HERG K+ CHANNEL FUNCTION IN MAMMALIAN CELLS AND APPLICATIONS TO THE CONTROL OF CANCER CELLS DIVISION
- Patent Title (中): 在哺乳动物细胞中抑制HERG K +通道功能和应用于癌细胞分裂的控制
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Application No.: PCT/CA2005/001574Application Date: 2005-10-14
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Publication No.: WO2006039806A1Publication Date: 2006-04-20
- Inventor: WANG, Zhiguo
- Applicant: INSTITUT DE CARDIOLOGIE DE MONTREAL , YANG, Baofeng , WANG, Zhiguo
- Applicant Address: 5000 Bélanger Est, Montreal, Quebec H1T 1C8 CA
- Assignee: INSTITUT DE CARDIOLOGIE DE MONTREAL,YANG, Baofeng,WANG, Zhiguo
- Current Assignee: INSTITUT DE CARDIOLOGIE DE MONTREAL,YANG, Baofeng,WANG, Zhiguo
- Current Assignee Address: 5000 Bélanger Est, Montreal, Quebec H1T 1C8 CA
- Agency: TESSIER, Louis
- Priority: US60/618,142 20041014
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A61K48/00 ; A61K31/7105 ; A61K31/4468 ; A61K31/18 ; A61K31/4545 ; A61P35/00
Abstract:
The use of an HERG channel inhibitor for controlling the proliferation of cancer cells. Examples of such HERG channel inhibitors include dofetilide, cisapride, E-4031 and a siRNA molecule targeting a sequence involved in the expression of an HERG channel. Other ERG channels are also targets for these inhibitors.
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