发明申请
WO2006058048A2 METHOD OF DETERMINING A CELLULAR RESPONSE TO A BIOLOGICAL AGENT
审中-公开
确定对生物代谢物的细胞响应的方法
- 专利标题： METHOD OF DETERMINING A CELLULAR RESPONSE TO A BIOLOGICAL AGENT
- 专利标题（中）： 确定对生物代谢物的细胞响应的方法
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申请号： PCT/US2005/042407申请日： 2005-11-21
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公开(公告)号： WO2006058048A2公开(公告)日： 2006-06-01
- 发明人: ROBERTSON, Barbara , LEAKE, Devin , ROBINSON, Kathryn , MARSHALL, William, S. , KHVOROVA, Anastasia
- 申请人： DHARMACON, INC. , ROBERTSON, Barbara , LEAKE, Devin , ROBINSON, Kathryn , MARSHALL, William, S. , KHVOROVA, Anastasia
- 申请人地址： 2650 Cresent Drive, Suite 100, Lafayette, CO 80026 US
- 专利权人： DHARMACON, INC.,ROBERTSON, Barbara,LEAKE, Devin,ROBINSON, Kathryn,MARSHALL, William, S.,KHVOROVA, Anastasia
- 当前专利权人： DHARMACON, INC.,ROBERTSON, Barbara,LEAKE, Devin,ROBINSON, Kathryn,MARSHALL, William, S.,KHVOROVA, Anastasia
- 当前专利权人地址： 2650 Cresent Drive, Suite 100, Lafayette, CO 80026 US
- 代理机构： STRINGHAM, John, C. et al.
- 优先权： US60/630,320 20041122; US60/678,165 20050504; US11/283,481 20051118; USnone 20051118; USnone 20051118; USnone 20051118
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/87 ; A61K48/00
摘要：
A method of determining a cellular response to a biological agent can be preformed in the presence of gene silencing. Such a method can include the use of siRNA in order to silence various genes in the cell in order to monitor the cellular response to the biological agent when a gene has been silenced. Accordingly, the response of a cell having a silenced gene to a biological agent can be indicative of which genes may be responsible for normal or abnormal cellular responses to various synthetic and natural biological agents such as active agents or pathogens.
