Invention Application
WO2006078414A2 METHODS AND COMPOSITIONS CONCERNING siRNA'S AS MEDIATORS OF RNA INTERFERENCE
审中-公开
关于siRNA作为RNA干扰介质的方法和组合物
- Patent Title: METHODS AND COMPOSITIONS CONCERNING siRNA'S AS MEDIATORS OF RNA INTERFERENCE
- Patent Title (中): 关于siRNA作为RNA干扰介质的方法和组合物
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Application No.: PCT/US2005/046779Application Date: 2005-12-21
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Publication No.: WO2006078414A2Publication Date: 2006-07-27
- Inventor: FORD, Lance, P. , KREBS, Joseph
- Applicant: AMBION, INC. , FORD, Lance, P. , KREBS, Joseph
- Applicant Address: 2130 Woodward Street, #200, Austin, Texas 78744-1832 US
- Assignee: AMBION, INC.,FORD, Lance, P.,KREBS, Joseph
- Current Assignee: AMBION, INC.,FORD, Lance, P.,KREBS, Joseph
- Current Assignee Address: 2130 Woodward Street, #200, Austin, Texas 78744-1832 US
- Agency: KRAWZSENEK, Michael, R.
- Priority: US11/020,560 20041223
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113
Abstract:
The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 basepairs in length; and delivering the siRNA into the cell. The siRNAs can be chemically synthesized RNA or an analog of a naturally occurring RNA.
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