The invention relates to antibiotic derivatives of formula (I) wherein: A represents -O-, S, -C(=O)-, -C(=NOR 6 )-; Z-B represents NCH 2 CH 2 , NCOCH 2 , NCH 2 CO, NCH 2 CH(OH), CHN(R 8 )CH 2 or CHN(R 8 )C0; D represents binuclear heteroaryl; Y 1 represents -CR 1 - or -N-, Y 2 represents -CR 2 - or -N-, Y 3 represents -CR 3 - or -N- and Y 4 represents -CR 4 - or -N-; U represents -NH-, -O- or -S- and V represents -N- or -CH-; W represents -CH 2 -, -O- or -NR 7 -; R 1 represents H, methyl, ethyl or halogen; R 2 , R 3 and R 4 each represent independently H, C 1 -C 4 alkyl, halogen, or C 1 -C 4 alkoxy; R 5 represents H, C 1 -C 4 alkyl or fluorine; R 6 represents H, C 1 -C 4 alkyl or EiTyI-C 1 -C 4 alkyl; R 7 represents H, C 1 -C 4 alkyl, aryl-Q-Q alkyl or -CH 2 -COOH; R 8 represents H, C 1 -C 4 alkyl or -CH 2 -COOH; with the provisos that if Z-B represents NCH 2 CH 2 , NCOCH 2 , NCH 2 CO or NCH 2 CH(OH), then W represents -CH 2 -; if A represents O or S, then W represents -CH 2 -; and only one or two of Y 1 , Y 2 , Y 3 and Y 4 can represent N at the same time.