A method and system for determining a location of a mobile communication device for an improvement of a positioning through a self-learning processing algorithm. In the method and system for determining a location of a mobile communication device, a self-learning processing unit batch processes GPS-based positioning results accumulated in a first self-learning database, and generates a sector direction value. Also, the self-learning processing unit generates optimized environment parameters, which is necessary for wireless network-based positioning, and basic data for a pattern matching, and updates the optimized environment parameters and basic data in a second self-learning database. Accordingly, the system for determining a location of a mobile communication device performs a positioning through a pattern matching method by using results accumulated in the second self-learning database.