发明申请
WO2007052058A1 INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS
审中-公开
流感疫苗，包括颗粒剂和免疫调节剂的组合
- 专利标题： INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS
- 专利标题（中）： 流感疫苗，包括颗粒剂和免疫调节剂的组合
-
申请号： PCT/GB2006/004133申请日： 2006-11-06
-
公开(公告)号： WO2007052058A1公开(公告)日： 2007-05-10
- 发明人: RAPPUOLI, Rino , O'HAGAN, Derek , DEL GUIDICE, Guiseppe
- 申请人： NOVARTIS VACCINES AND DIAGNOSTICS SRL , RAPPUOLI, Rino , O'HAGAN, Derek , DEL GUIDICE, Guiseppe
- 申请人地址： Via Fiorentina 1, I-53100 Siena IT
- 专利权人： NOVARTIS VACCINES AND DIAGNOSTICS SRL,RAPPUOLI, Rino,O'HAGAN, Derek,DEL GUIDICE, Guiseppe
- 当前专利权人： NOVARTIS VACCINES AND DIAGNOSTICS SRL,RAPPUOLI, Rino,O'HAGAN, Derek,DEL GUIDICE, Guiseppe
- 当前专利权人地址： Via Fiorentina 1, I-53100 Siena IT
- 代理机构： MARSHALL, Cameron, John et al.
- 优先权： US60/734,026 20051104; US60/735,468 20051111
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; A61K39/39
摘要：
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgGl). This response can be shifted towards a THl response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.
