Invention Application
- Patent Title: HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
- Patent Title (中): ATP结合蛋白转运蛋白的杂环调节剂
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Application No.: PCT/US2006/043289Application Date: 2006-11-08
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Publication No.: WO2007056341A1Publication Date: 2007-05-18
- Inventor: HADIDA RUAH, Sara , HAMILTON, Matthew , MILLER, Mark , GROOTENHUIS, Peter, D., J. , BEAR, Brian , MCCARTHY, Jason , ZHOU, Jinglan
- Applicant: VERTEX PHARMACEUTICALS INCORPORATED , HADIDA RUAH, Sara , HAMILTON, Matthew , MILLER, Mark , GROOTENHUIS, Peter, D., J. , BEAR, Brian , MCCARTHY, Jason , ZHOU, Jinglan
- Applicant Address: 130 WAVERLY STREET, Cambridge, MA 02139 US
- Assignee: VERTEX PHARMACEUTICALS INCORPORATED,HADIDA RUAH, Sara,HAMILTON, Matthew,MILLER, Mark,GROOTENHUIS, Peter, D., J.,BEAR, Brian,MCCARTHY, Jason,ZHOU, Jinglan
- Current Assignee: VERTEX PHARMACEUTICALS INCORPORATED,HADIDA RUAH, Sara,HAMILTON, Matthew,MILLER, Mark,GROOTENHUIS, Peter, D., J.,BEAR, Brian,MCCARTHY, Jason,ZHOU, Jinglan
- Current Assignee Address: 130 WAVERLY STREET, Cambridge, MA 02139 US
- Agency: LIU, Yi
- Priority: US60/734,506 20051108; US60/754,086 20051227; US60/802,458 20060522
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D405/14 ; C07D213/75 ; A61K31/5585 ; A61K31/4418 ; A61P11/00
Abstract:
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Information query
