Contemplated padded undergarments are form-fitted and have a higher than normal ratio of waist circumference to leg circumference and include a padded area that covers substantially the entire contact area of buttocks and legs with a chair when a person wearing such undergarment is sitting on the chair. Such undergarments are particularly advantageous to provide symptomatic relief for a person diagnosed with HIV infection, a neoplastic disease, chronic diabetes, and/or advanced age, which is typically accompanied by lipoatrophy, lipodystrophy, and/or sarcopenia.