发明申请
WO2008022146A2 POLYMER-SURFACTANT NANOPARTICLES FOR SUSTAINED RELEASE OF COMPOUNDS
审中-公开
用于持续释放化合物的聚合物 - 表面活性剂纳米颗粒
- 专利标题： POLYMER-SURFACTANT NANOPARTICLES FOR SUSTAINED RELEASE OF COMPOUNDS
- 专利标题（中）： 用于持续释放化合物的聚合物 - 表面活性剂纳米颗粒
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申请号： PCT/US2007/075925申请日： 2007-08-14
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公开(公告)号： WO2008022146A2公开(公告)日： 2008-02-21
- 发明人: PANYAM, Jayanth , PATIL, Mahesh, D. Chavan
- 申请人： WAYNE STATE UNIVERSITY , PANYAM, Jayanth , PATIL, Mahesh, D. Chavan
- 申请人地址： 5057 Woodward, Suite 6306 Detroit, Michigan 48202 US
- 专利权人： WAYNE STATE UNIVERSITY,PANYAM, Jayanth,PATIL, Mahesh, D. Chavan
- 当前专利权人： WAYNE STATE UNIVERSITY,PANYAM, Jayanth,PATIL, Mahesh, D. Chavan
- 当前专利权人地址： 5057 Woodward, Suite 6306 Detroit, Michigan 48202 US
- 代理机构： POTTER, Jane, E.R. et al.
- 优先权： US60/837,808 20060814
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/46
摘要：
A polymer-surfactant nanoparticle formulation, using the anionic surfactant aerosol OT (AOT) and polysaccharide polymer alginate, is used for sustained release of water-soluble drugs. The AOT-alginate nanoparticles are suitable for encapsulating doxorubicin, verapamil and clonidine, as well as therapeutic agents effective against dermal conditions such as psoriasis. The nanoparticles are also suitable for encapsulating photo-activated compounds such as methylene blue for use in photo-dynamic therapy of cancer and other diseases, and for treating tumor cells that exhibit resistance to at least one chemotherapeutic drug.
