发明申请
- 专利标题： HETEROCYCLIC FXR BINDING COMPOUNDS
- 专利标题（中）： 杂环FXR结合化合物
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申请号： PCT/EP2007/007556申请日： 2007-08-29
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公开(公告)号： WO2008025539A1公开(公告)日： 2008-03-06
- 发明人: KREMOSER, Claus , DEUSCHLE, Ulrich , ABEL, Ulrich , SCHULZ, Andreas
- 申请人： PHENEX PHARMACEUTICALS AG , KREMOSER, Claus , DEUSCHLE, Ulrich , ABEL, Ulrich , SCHULZ, Andreas
- 申请人地址： J542N Werksgelände BASF 67056 Ludwigshafen DE
- 专利权人： PHENEX PHARMACEUTICALS AG,KREMOSER, Claus,DEUSCHLE, Ulrich,ABEL, Ulrich,SCHULZ, Andreas
- 当前专利权人： PHENEX PHARMACEUTICALS AG,KREMOSER, Claus,DEUSCHLE, Ulrich,ABEL, Ulrich,SCHULZ, Andreas
- 当前专利权人地址： J542N Werksgelände BASF 67056 Ludwigshafen DE
- 代理机构： GOLDBACH, Klara
- 优先权： US60/840,912 20060829; EP06018024.7 20060829
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; A61K31/4155 ; A61P3/10 ; A61P29/00 ; A61P25/30
摘要：
The present invention relates to compounds of formula (I) which bind to the NRl H4 receptor (FXR) and act as agonists or partial agonists of the NRl H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds, and an enantiomer, diasterecmer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein X is (a) or (b) or (c) or (d), and the rest of the variables are as specified in claim 1.
