发明申请
WO2008070158A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
审中-公开
制备2-氨基-5-氰基苯甲酸衍生物的方法
- 专利标题： PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
- 专利标题（中）： 制备2-氨基-5-氰基苯甲酸衍生物的方法
-
申请号： PCT/US2007/025005申请日： 2007-12-05
-
公开(公告)号： WO2008070158A1公开(公告)日： 2008-06-12
- 发明人: BRUENING, Joerg , CASALNUOVO, Albert, Loren , GRUSHIN, Vladimir
- 申请人： E. I. DU PONT DE NEMOURS AND COMPANY , BRUENING, Joerg , CASALNUOVO, Albert, Loren , GRUSHIN, Vladimir
- 申请人地址： 1007 Market Street Wilmington, Delaware 19898 US
- 专利权人： E. I. DU PONT DE NEMOURS AND COMPANY,BRUENING, Joerg,CASALNUOVO, Albert, Loren,GRUSHIN, Vladimir
- 当前专利权人： E. I. DU PONT DE NEMOURS AND COMPANY,BRUENING, Joerg,CASALNUOVO, Albert, Loren,GRUSHIN, Vladimir
- 当前专利权人地址： 1007 Market Street Wilmington, Delaware 19898 US
- 代理机构： HEISER, David, E.
- 优先权： US60/873,058 20061206
- 主分类号： C07C253/14
- IPC分类号： C07C253/14
摘要：
Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with at least one compound of Formula 3 in the presence of a solvent comprising one or more organic solvents selected from ethers and nitriles and a catalytically effective amount of a palladium complex comprising at least one tertiary phosphine ligand of Formula (4) wherein R 1 is NHR 3 or OR 4 ; R 2 is CH 3 or Cl; R 3 is H, C 1 - C 4 alkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl; R 4 is H or C 1 -C 4 alkyl; M 1 is an alkali metal; and R 5 , R 6 and R 7 are defined in the disclosure; provided that when R 2 is Cl, then X is Br. Also disclosed is a method for preparing a compound of Formula 5 wherein R 14 , R 15 , R 16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula (1) by the aforedescribed method.
