The invention relates to an air-conditioning system (12) for a motor vehicle (10) for the engine-independent air-conditioning thereof, said system comprising a fuel cell system (14) having a plurality of functional units (18, 26, 42) for treating the fuel; and a coolant circuit (16) that can be driven by the fuel cell system (14) and that comprises a plurality of functional units (56, 58, 60, 62) that are fluidically interconnected. The invention is characterized in that at least one of the functional units (18, 26, 42, 56, 58, 60, 62) and/or the fuel cell system (14) and/or the coolant circuit (16) can be fitted in the air-conditioning system (12) as a detachable module by means of at least one interface (100 - 146), said interface being adapted to fit a replacement unit replacing the detachable module (14, 18, 26, 42, 56, 58, 60, 62) in the air-conditioning system (12). The invention also relates to a motor vehicle comprising said air-conditioning system.