Invention Application
WO2008137791A1 USE OF TP MODULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS IN ASPIRIN SENSITIVE AND OTHER POPULATIONS
审中-公开
使用TP调节剂治疗腹泻敏感型和其他人群中的心血管疾病
- Patent Title: USE OF TP MODULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS IN ASPIRIN SENSITIVE AND OTHER POPULATIONS
- Patent Title (中): 使用TP调节剂治疗腹泻敏感型和其他人群中的心血管疾病
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Application No.: PCT/US2008/062565Application Date: 2008-05-02
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Publication No.: WO2008137791A1Publication Date: 2008-11-13
- Inventor: PHILLIPS, David, R. , ANDRE, Patrick , HOMCY, Charles, J.
- Applicant: PORTOLA PHARMACEUTICALS, INC. , PHILLIPS, David, R. , ANDRE, Patrick , HOMCY, Charles, J.
- Applicant Address: 270 E. Grand Avenue, Suite 22 South San Francisco, California 94080 US
- Assignee: PORTOLA PHARMACEUTICALS, INC.,PHILLIPS, David, R.,ANDRE, Patrick,HOMCY, Charles, J.
- Current Assignee: PORTOLA PHARMACEUTICALS, INC.,PHILLIPS, David, R.,ANDRE, Patrick,HOMCY, Charles, J.
- Current Assignee Address: 270 E. Grand Avenue, Suite 22 South San Francisco, California 94080 US
- Agency: LAHERTY, Carol, D. et al.
- Priority: US60/915,784 20070503; US60/915,785 20070503; US60/947,316 20070629; US60/947,289 20070629
- Main IPC: C12N9/02
- IPC: C12N9/02
Abstract:
The present invention provides methods and compositions useful in the treatment or prevention of cardiovascular disorders in individuals for whom therapy with a COX-1 enzyme inhibitor is not feasible due to sensitivity, intolerance, or resistance to the inhibitor. Additionally, the invention provides methods of treating cardiovascular disorders in an individual who is receiving a therapeutically effective dose of a TP modulator and is instructed or advised to avoid and/or not to take aspirin or another COX-1 inhibitor.
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