A frame compensation method is provided, which includes the following steps: obtaining the length of a lost frame and a correct frame; judging the length of a correct frame is integral power times of two of the length of a lost frame, then obtaining the data sequence whose length is same as the length of the lost frame according to the correct frame; compensating the lost frame according to the said data sequence, obtaining the compensated data frame. A frame compensation system is also provided, which includes: a first length obtaining module, a second length obtaining module, a data sequence obtaining module and compensation module. Lost frames with various formats are compensated according to correct frames with various formats, so that the limitation of the prior art that the lost frame with single format is justly compensated according to the correct frame with single format is conquered, and the effect of the data frame after compensation is better than that of filling comfort noise.