发明申请
- 专利标题： A NOVEL PROCESS FOR THE PREPARATION OF PREGABALIN
- 专利标题（中）： 制备PREGABALIN的新方法
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申请号： PCT/IN2008/000174申请日： 2008-03-24
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公开(公告)号： WO2009001372A2公开(公告)日： 2008-12-31
- 发明人: SATYANARAYANA REDDY, Manne , THIRUMALAI RAJAN, Srinivasan , ESWARAIAH, Sajja , SATYANARAYANA, Revu
- 申请人： SATYANARAYANA REDDY, Manne , THIRUMALAI RAJAN, Srinivasan , ESWARAIAH, Sajja , SATYANARAYANA, Revu
- 申请人地址： H.No: 8-3-167/D/16 Kalyan Nagar Hyderabad 500 038 Andhra Pradesh IN
- 专利权人： SATYANARAYANA REDDY, Manne,THIRUMALAI RAJAN, Srinivasan,ESWARAIAH, Sajja,SATYANARAYANA, Revu
- 当前专利权人： SATYANARAYANA REDDY, Manne,THIRUMALAI RAJAN, Srinivasan,ESWARAIAH, Sajja,SATYANARAYANA, Revu
- 当前专利权人地址： H.No: 8-3-167/D/16 Kalyan Nagar Hyderabad 500 038 Andhra Pradesh IN
- 代理机构： SATYANARAYANA REDDY, Manne
- 优先权： IN1344/CHE/2007 20070625; IN114/CHE/2008 20080114
- 主分类号： C07C255/19
- IPC分类号： C07C255/19 ; C07C253/14
摘要：
The present invention encompasses novel intermediates of pregabalin, namely 3 -cyano-5 -methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.
