Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. In one embodiment, the closure device includes a vessel locating member (92), an anchor (112) and a sealing material (120). The closure device may be configured to deploy the anchor (112) and the sealing material (120) outside of a hole in a blood vessel to close the hole. The vessel locating member (92) may be used to locate the blood vessel to ensure that the anchor (112) and/or the sealing material (120) are properly placed adjacent to the hole. The closure device may also include a tamper member (126) configured to push or tamp the sealing material (120) against the anchor (112). The closure device may also include a suture (118) that is used to hold the sealing material (120) and the anchor (112) together adjacent to the hole in the blood vessel.