Invention Application
WO2009155041A3 METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH
审中-公开
调节HEMATOPOIETIC STEM CELL GROWTH的方法
- Patent Title: METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH
- Patent Title (中): 调节HEMATOPOIETIC STEM CELL GROWTH的方法
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Application No.: PCT/US2009045442Application Date: 2009-05-28
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Publication No.: WO2009155041A3Publication Date: 2010-03-11
- Inventor: ZON LEONARD I , NORTH TRISTA E , GOESSLING WOLFRAM
- Applicant: CHILDRENS MEDICAL CENTER , GEN HOSPITAL CORP , BETH ISRAEL HOSPITAL , BRIGHAM & WOMENS HOSPITAL , ZON LEONARD I , NORTH TRISTA E , GOESSLING WOLFRAM
- Assignee: CHILDRENS MEDICAL CENTER,GEN HOSPITAL CORP,BETH ISRAEL HOSPITAL,BRIGHAM & WOMENS HOSPITAL,ZON LEONARD I,NORTH TRISTA E,GOESSLING WOLFRAM
- Current Assignee: CHILDRENS MEDICAL CENTER,GEN HOSPITAL CORP,BETH ISRAEL HOSPITAL,BRIGHAM & WOMENS HOSPITAL,ZON LEONARD I,NORTH TRISTA E,GOESSLING WOLFRAM
- Priority: US5662108 2008-05-28; US17772009 2009-05-13
- Main IPC: C12N5/02
- IPC: C12N5/02 ; A61K31/04 ; A61P37/06 ; C12N5/00
Abstract:
Described herein are methods, compositions and kits related to manipulating hematopoietic stem cells (HSC) and more particularly to methods, compositions and kits related to increasing the number of hematopoietic stem cells in vitro, ex vivo and/or in vivo. Also described are methods, compositions and kits related to making an expanded population of HSC and methods, compositions and kits related to using the expanded population of HSC. For example, HSC growth may be enhanced by contacting the nascent stem cells or HSC with an agent that stimulates the nitric oxide signaling pathway.
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