Methods and apparatus are disclosed for estimating inter-cell interference levels for resource elements of a received Orthogonal Frequency-Division Multiplexing (OFDM) signal. In an exemplary method in a wireless receiver, a reference symbol interference levels is measured for each of a plurality of reference symbols in a received OFDM signal, and interference scaling factors are mapped to each of a plurality of resource elements of the received OFDM signal. Each interference scaling factor reflects the probability that the corresponding resource element or group of resource elements is subject to interference from an interfering OFDM signal. Interference levels for each of the resource elements are then estimated as a function of the measured reference symbol interference levels and the interference scaling factors.