- 专利标题： SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS
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申请号： PCT/US2009/069813申请日： 2009-12-30
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公开(公告)号： WO2010078421A8公开(公告)日： 2010-07-08
- 发明人: ALI, Syed, M. , ASHWELL, Mark , TANDON, Manish , YANG, Rui-yang , LIU, Yanbin , VENSEL, David , EATHIRAJ, Sudharshan , PALMA, Rocio , LAPIERRE, Jean-marc , WESTLUND, Neil , WU, Hui , NAMDEV, Nivedita , KELLEHER, Eugene
- 申请人： ARQULE, INC. , ALI, Syed, M. , ASHWELL, Mark , TANDON, Manish , YANG, Rui-yang , LIU, Yanbin , VENSEL, David , EATHIRAJ, Sudharshan , PALMA, Rocio , LAPIERRE, Jean-marc , WESTLUND, Neil , WU, Hui , NAMDEV, Nivedita , KELLEHER, Eugene
- 申请人地址： 19 Presidential Way Woburn, MA 01801 US
- 专利权人： ARQULE, INC.,ALI, Syed, M.,ASHWELL, Mark,TANDON, Manish,YANG, Rui-yang,LIU, Yanbin,VENSEL, David,EATHIRAJ, Sudharshan,PALMA, Rocio,LAPIERRE, Jean-marc,WESTLUND, Neil,WU, Hui,NAMDEV, Nivedita,KELLEHER, Eugene
- 当前专利权人： ARQULE, INC.,ALI, Syed, M.,ASHWELL, Mark,TANDON, Manish,YANG, Rui-yang,LIU, Yanbin,VENSEL, David,EATHIRAJ, Sudharshan,PALMA, Rocio,LAPIERRE, Jean-marc,WESTLUND, Neil,WU, Hui,NAMDEV, Nivedita,KELLEHER, Eugene
- 当前专利权人地址： 19 Presidential Way Woburn, MA 01801 US
- 代理机构： ELRIFI, Ivor, R. et al.
- 优先权： US61/141,439 20081230; US61/260,505 20091112
- 主分类号： C07D221/10
- IPC分类号： C07D221/10 ; C07D401/12 ; C07D471/10 ; A61K31/55 ; A61P35/00
摘要：
The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
