Invention Application
- Patent Title: DIAGNOSTIC METHOD USING PALB2
- Patent Title (中): 诊断方法使用PALB2
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Application No.: PCT/US2010/026290Application Date: 2010-03-05
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Publication No.: WO2010102160A2Publication Date: 2010-09-10
- Inventor: VOGELSTEIN, Bert , KINZLER, Kenneth W. , PARSONS, D. Williams , JONES, Sian , KERN, Scott , HRUBAN, Ralph , ESHLEMAN, James R. , GOGGINS, Michael , KLEIN, Alison , HIDALGO, Manuel , VELCULESCU, Victor E.
- Applicant: THE JOHNS HOPKINS UNIVERSITY , VOGELSTEIN, Bert , KINZLER, Kenneth W. , PARSONS, D. Williams , JONES, Sian , KERN, Scott , HRUBAN, Ralph , ESHLEMAN, James R. , GOGGINS, Michael , KLEIN, Alison , HIDALGO, Manuel , VELCULESCU, Victor E.
- Applicant Address: 3400 North Charles Street Baltimore, Maryland 21218 US
- Assignee: THE JOHNS HOPKINS UNIVERSITY,VOGELSTEIN, Bert,KINZLER, Kenneth W.,PARSONS, D. Williams,JONES, Sian,KERN, Scott,HRUBAN, Ralph,ESHLEMAN, James R.,GOGGINS, Michael,KLEIN, Alison,HIDALGO, Manuel,VELCULESCU, Victor E.
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY,VOGELSTEIN, Bert,KINZLER, Kenneth W.,PARSONS, D. Williams,JONES, Sian,KERN, Scott,HRUBAN, Ralph,ESHLEMAN, James R.,GOGGINS, Michael,KLEIN, Alison,HIDALGO, Manuel,VELCULESCU, Victor E.
- Current Assignee Address: 3400 North Charles Street Baltimore, Maryland 21218 US
- Agency: KAGAN, Sarah A.
- Priority: US61/157,700 20090305; US61/264,019 20091124
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/68 ; G01N33/574
Abstract:
The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.
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