The present disclosure generally relates to wet wipes having liquid wipe compositions that including an anti-adhesion component that reduces sheet-to- sheet adhesion, improves the stack height, increases flexibility and maintains strength in the wet wipe. The liquid wipe compositions include an organopolysiloxane having the following structure:(I) wherein p + q = 0 to 2000, R1 is independently selected from a monovalent hydrocarbon group or hydroxyl group, and R2 and R3 are independently selected from a monovalent hydrocarbon group, a hydroxyl group, a monovalent hydrocarbon group functional in amine, a monovalent hydrocarbon group functional in polyether, a monovalent hydrocarbon group functional in quaternary, and a monovalent hydrocarbon group functional in polyampholyte.