Invention Application
WO2010136780A1 METHOD TO DETECT AND SEQUENCE POST TRANSLATIONALLY MODIFIED PEPTIDES
审中-公开
检测和序列后翻译修饰肽的方法
- Patent Title: METHOD TO DETECT AND SEQUENCE POST TRANSLATIONALLY MODIFIED PEPTIDES
- Patent Title (中): 检测和序列后翻译修饰肽的方法
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Application No.: PCT/GB2010/001077Application Date: 2010-05-28
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Publication No.: WO2010136780A1Publication Date: 2010-12-02
- Inventor: HUGHES, Christopher, John , MCKENNA, Thérèse , GORDON, David , KENNY, Daniel, James
- Applicant: MICROMASS UK LIMITED , HUGHES, Christopher, John , MCKENNA, Thérèse , GORDON, David , KENNY, Daniel, James
- Applicant Address: Floats Road Wythenshawe Manchester M23 9LZ GB
- Assignee: MICROMASS UK LIMITED,HUGHES, Christopher, John,MCKENNA, Thérèse,GORDON, David,KENNY, Daniel, James
- Current Assignee: MICROMASS UK LIMITED,HUGHES, Christopher, John,MCKENNA, Thérèse,GORDON, David,KENNY, Daniel, James
- Current Assignee Address: Floats Road Wythenshawe Manchester M23 9LZ GB
- Agency: JEFFREY, Philip, Michael
- Priority: GB0909285.9 20090529; US61/182,123 20090529
- Main IPC: G01N33/68
- IPC: G01N33/68 ; H01J49/00
Abstract:
A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan (1) is performed. A negative ion high resolution MS scan (4) is then performed and then MRM channels in positive ion mode are determined and monitored (5). A positive ion MS/MS scan is then performed.
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