Invention Application
WO2011036191A3 GOLD -COATED MAGNETIC GLYCONANOPARTICLES FUNCTIONALISED WITH PROTEINS FOR USE AS DIAGNOSTIC AND THERAPEUTIC AGENTS
审中-公开
功能性蛋白质的金属化合物磁性蛋白质用作诊断和治疗药物
- Patent Title: GOLD -COATED MAGNETIC GLYCONANOPARTICLES FUNCTIONALISED WITH PROTEINS FOR USE AS DIAGNOSTIC AND THERAPEUTIC AGENTS
- Patent Title (中): 功能性蛋白质的金属化合物磁性蛋白质用作诊断和治疗药物
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Application No.: PCT/EP2010064012Application Date: 2010-09-23
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Publication No.: WO2011036191A3Publication Date: 2011-05-26
- Inventor: PENADES ULLATE SOLEDAD , GARCIA MARTIN ISABEL , GALLO PARAMO JUAN
- Applicant: CT DE INVESTIGACION COOPERATIVA EN BIOMATERIALES CIC BIOMAGUNE ASOC , PENADES ULLATE SOLEDAD , GARCIA MARTIN ISABEL , GALLO PARAMO JUAN
- Assignee: CT DE INVESTIGACION COOPERATIVA EN BIOMATERIALES CIC BIOMAGUNE ASOC,PENADES ULLATE SOLEDAD,GARCIA MARTIN ISABEL,GALLO PARAMO JUAN
- Current Assignee: CT DE INVESTIGACION COOPERATIVA EN BIOMATERIALES CIC BIOMAGUNE ASOC,PENADES ULLATE SOLEDAD,GARCIA MARTIN ISABEL,GALLO PARAMO JUAN
- Priority: EP09382185 2009-09-25
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K49/18
Abstract:
Gold-coated nanoparticles comprising: a) a magnetic core Of XFe2O4 wherein X is a metal selected from the group consisting of Fe, Mn, and Co; b) carbohydrates covalently coupled through a spacer to the gold-coated nanoparticle, wherein said spacer has a thiol linking it to the nanoparticle; and c) an immunoglobulin-binding protein coupled to the gold-coated nanoparticle through an amphiphilic molecule, comprising a functional group capable of coupling the protein and through a thiol group which is attached to the gold coating of the nanoparticle, where a immunoglobulin-binding protein can be coupled to further bioconjugation with antibodies. Said nanoparticles have been found to be useful as contrast agents by MRI.
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