Invention Application
- Patent Title: DLL4-BINDING MOLECULES
- Patent Title (中): DLL4-BINDING分子
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Application No.: PCT/EP2010064693Application Date: 2010-10-01
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Publication No.: WO2011039368A3Publication Date: 2011-06-23
- Inventor: BORGES ERIC , GSCHWIND ANDREAS , BOUCNEAU JOACHIM , DE TAVERNIER EVELYN , KOLKMAN JOOST , MERCHIERS PASCAL , VAN HOORICK DIANE
- Applicant: BOEHRINGER INGELHEIM INT , BORGES ERIC , GSCHWIND ANDREAS , BOUCNEAU JOACHIM , DE TAVERNIER EVELYN , KOLKMAN JOOST , MERCHIERS PASCAL , VAN HOORICK DIANE
- Assignee: BOEHRINGER INGELHEIM INT,BORGES ERIC,GSCHWIND ANDREAS,BOUCNEAU JOACHIM,DE TAVERNIER EVELYN,KOLKMAN JOOST,MERCHIERS PASCAL,VAN HOORICK DIANE
- Current Assignee: BOEHRINGER INGELHEIM INT,BORGES ERIC,GSCHWIND ANDREAS,BOUCNEAU JOACHIM,DE TAVERNIER EVELYN,KOLKMAN JOOST,MERCHIERS PASCAL,VAN HOORICK DIANE
- Priority: EP09172132 2009-10-02
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P35/00
Abstract:
DII4-binding molecules, preferably DII4-binding immunoglobulin single variable domains like VHHs and VHs, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with DII4-mediated effects on angiogenesis. Bispecific DII4-binding molecules that also bind to VEGF-A. Nucleic acids encoding DII4-binding molecules, host cells and methods for preparing same.
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