Invention Application
WO2011048503A3 PEPTIDES THAT BIND THE ALPHA-FETOPROTEIN (AFP) RECEPTOR AND USES THEREOF
审中-公开
含有ALPHA-FETOPROTEIN（AFP）受体的蛋白及其用途
- Patent Title: PEPTIDES THAT BIND THE ALPHA-FETOPROTEIN (AFP) RECEPTOR AND USES THEREOF
- Patent Title (中): 含有ALPHA-FETOPROTEIN（AFP）受体的蛋白及其用途
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Application No.: PCT/IB2010003152Application Date: 2010-10-21
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Publication No.: WO2011048503A3Publication Date: 2011-06-16
- Inventor: MORO RICARDO J , SCHMID RALPH H
- Applicant: MORO RICARDO J , SCHMID RALPH H
- Assignee: MORO RICARDO J,SCHMID RALPH H
- Current Assignee: MORO RICARDO J,SCHMID RALPH H
- Priority: US27950109 2009-10-22
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61K9/127 ; A61K38/17 ; A61K47/48 ; A61K49/00 ; A61K51/08 ; C07K7/06 ; C07K7/08 ; C07K14/705 ; C07K16/18 ; C07K16/42 ; C07K17/04 ; C12N7/01 ; C12N15/87 ; G01N33/53 ; G01N33/543 ; G01N33/574 ; G01N33/68
Abstract:
The present invention provides an active binding sequence of mammalian alpha- fetoprotein (AFP) to the receptor of AFP (AFPr or RECAP). The sequence is embodied in peptides comprising Lys-Glx-Glx-Xaa-Leu-Ile-Asn (SEQ. ID. NO: 1) and variants thereof, wherein GIx means GIn or GIu, each GIx being selected independently of the other, and Xaa represents Phe or Leu. The peptides bind a site of the AFP receptor. This peptide can be used as a substitute for AFP in the detection, purification and imagining of RECAF. This peptide, as it binds to RECAF which is elevated in cancer cells, allows for a method of diagnostic determination of cancer or chemotherapeutic delivery using cytotoxic or radiological agents.
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