发明申请
- 专利标题： 1-DEOXY ANALOGS OF VITAMIN D-RELATED COMPOUNDS
- 专利标题（中）： 维生素D相关化合物的1-去氧模拟物
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申请号： PCT/US2011021129申请日： 2011-01-13
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公开(公告)号： WO2011088209A3公开(公告)日： 2015-09-03
- 发明人: POSNER GARY H , HESS LINDSEY C , KALINDA ALVIN S , SLACK RACHEL D , SAHA UTTAM , PETKOVICH P MARTIN
- 申请人： CYTOCHROMA INC , UNIV JOHNS HOPKINS , POSNER GARY H , HESS LINDSEY C , KALINDA ALVIN S , SLACK RACHEL D , SAHA UTTAM , PETKOVICH P MARTIN
- 专利权人： CYTOCHROMA INC,UNIV JOHNS HOPKINS,POSNER GARY H,HESS LINDSEY C,KALINDA ALVIN S,SLACK RACHEL D,SAHA UTTAM,PETKOVICH P MARTIN
- 当前专利权人： CYTOCHROMA INC,UNIV JOHNS HOPKINS,POSNER GARY H,HESS LINDSEY C,KALINDA ALVIN S,SLACK RACHEL D,SAHA UTTAM,PETKOVICH P MARTIN
- 优先权： US29474110 2010-01-13
- 主分类号： C07C251/40
- IPC分类号： C07C251/40 ; A61K31/59 ; A61K31/592 ; A61K31/593 ; A61P17/06 ; A61P19/10 ; A61P35/00 ; C07C317/10 ; C07C381/10
摘要：
This present disclosure is directed to novel prodrugs of activated vitamin D3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases.
