Regulator with simplified and secure-fit support for gas cylinders, comprising an integrated support (1, 2, 3, 4) for mounting directly and without the use of tools on cylinders comprising valves, and a safety knob (5) guarded against any unwanted removal, such as, for example, in the means of transport and the vibrating machinery used in factories or on worksites. The assembly between regulator and its support is permanent and compact, and potentially allows the full cylinder to be grasped because of the robust and ergonomic design. The system is supplemented by the provision of a central pressure gauge incorporated into the regulator, intended to check the fill condition of the cylinder.