发明申请
WO2011139375A1 ANTIBODIES DIRECTED AGAINST CARBONIC ANHYDRASE IX AND METHODS AND USES THEREOF
审中-公开
针对碳氢化合物IX的抗体方法及其用途
- 专利标题： ANTIBODIES DIRECTED AGAINST CARBONIC ANHYDRASE IX AND METHODS AND USES THEREOF
- 专利标题（中）： 针对碳氢化合物IX的抗体方法及其用途
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申请号： PCT/US2011/000796申请日： 2011-05-06
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公开(公告)号： WO2011139375A1公开(公告)日： 2011-11-10
- 发明人: RENNER, Christoph , BAUER, Stefan , PLESKO, Margarita , HULIKOVA, Alzbeta , SWIETACH, Pawel
- 申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , UNIVERSITY OF ZURICH , RENNER, Christoph , BAUER, Stefan , PLESKO, Margarita , HULIKOVA, Alzbeta , SWIETACH, Pawel
- 申请人地址： 666 Third Avenue New York, NY 10017 US
- 专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD,CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD,UNIVERSITY OF ZURICH,RENNER, Christoph,BAUER, Stefan,PLESKO, Margarita,HULIKOVA, Alzbeta,SWIETACH, Pawel
- 当前专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD,CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD,UNIVERSITY OF ZURICH,RENNER, Christoph,BAUER, Stefan,PLESKO, Margarita,HULIKOVA, Alzbeta,SWIETACH, Pawel
- 当前专利权人地址： 666 Third Avenue New York, NY 10017 US
- 代理机构： DIETZEL, Christine, E.
- 优先权： US61/343,974 20100506
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00
摘要：
Specific binding members, particularly antibodies and fragments thereof, which bind to Carbonic Anhydrase IX (CAIX) are provided, particularly including recognizing both human and mouse CAIX and blocking or inhibiting CAIX activity. These antibodies are useful in the diagnosis and treatment of cancer and in conditions associated with hypoxia and/or elevated CAIX activity. The anti-CAIX antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti¬ cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies MSC 1 through MSC 12 whose sequences are provided herein.
