Embodiments herein relate generally to the field of footwear, and more particularly to components of performance footwear, such as midsoles, as well as methods of making midsoles. In various embodiments, multiple response property midsoles and/or portions of footwear are provided that may include strategically arranged multiple response property areas having blended transition zones disposed there between. Such blended transition zones may help facilitate a more fluid foot movement, improve manufacturing and production techniques, and prevent injury to the foot, ankle, and/or legs during exercise, such as running, hiking, walking, and other impact-generating activities.