Invention Application
WO2011162820A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
审中-公开
用于诊断和预防肾损伤和肾功能衰竭的方法和组合
- Patent Title: METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
- Patent Title (中): 用于诊断和预防肾损伤和肾功能衰竭的方法和组合
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Application No.: PCT/US2011/001127Application Date: 2011-06-23
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Publication No.: WO2011162820A1Publication Date: 2011-12-29
- Inventor: ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
- Applicant: ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
- Applicant Address: Blg 2, R. 645 3550 General Atomics Court San Diego, CA 92121 US
- Assignee: ASTUTE MEDICAL, INC.,ANDERBERG, Joseph,GRAY, Jeff,MCPHERSON, Paul,NAKAMURA, Kevin,KAMPF, James, Patrick
- Current Assignee: ASTUTE MEDICAL, INC.,ANDERBERG, Joseph,GRAY, Jeff,MCPHERSON, Paul,NAKAMURA, Kevin,KAMPF, James, Patrick
- Current Assignee Address: Blg 2, R. 645 3550 General Atomics Court San Diego, CA 92121 US
- Agency: WHITTAKER, Michael, A. et al.
- Priority: US61/364,300 20100714; US61/357,965 20100623; US61/364,304 20100714; US61/357,956 20100623
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G01N33/53
Abstract:
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cancer antigen CA 15-3, C-C Motif chemokine 18, C-C Motif chemokine 24, Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.
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