Invention Application
- Patent Title: LUMINESCENT DYES WITH A WATER-SOLUBLE INTRAMOLECULAR BRIDGE AND THEIR BIOLOGICAL CONJUGATES
- Patent Title (中): 水溶性分子间电桥发光染料及其生物共轭物
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Application No.: PCT/US2011/044776Application Date: 2011-07-21
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Publication No.: WO2012012595A2Publication Date: 2012-01-26
- Inventor: DIWU, Zhenjun , MENG, Qinglin , LIAO, Jinfang , GUO, Haitao , DUBROVSKY, Timothy , ABRAMS, Barnaby
- Applicant: BECTON, DICKINSON AND COMPANY , AAT BIOQUEST, INC. , DIWU, Zhenjun , MENG, Qinglin , LIAO, Jinfang , GUO, Haitao , DUBROVSKY, Timothy , ABRAMS, Barnaby
- Applicant Address: 1 Becton Drive Franklin Lakes, NJ 07417 US
- Assignee: BECTON, DICKINSON AND COMPANY,AAT BIOQUEST, INC.,DIWU, Zhenjun,MENG, Qinglin,LIAO, Jinfang,GUO, Haitao,DUBROVSKY, Timothy,ABRAMS, Barnaby
- Current Assignee: BECTON, DICKINSON AND COMPANY,AAT BIOQUEST, INC.,DIWU, Zhenjun,MENG, Qinglin,LIAO, Jinfang,GUO, Haitao,DUBROVSKY, Timothy,ABRAMS, Barnaby
- Current Assignee Address: 1 Becton Drive Franklin Lakes, NJ 07417 US
- Agency: HIGHET, David et al.
- Priority: US13/181,107 20110712; US61/399,995 20100721
- Main IPC: C09B11/24
- IPC: C09B11/24 ; C09B23/00 ; C09B49/06 ; G01N33/533
Abstract:
Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses.
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