Invention Application
- Patent Title: SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
- Patent Title (中): 取代的羟基酸及其用途
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Application No.: PCT/US2011/056344Application Date: 2011-10-14
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Publication No.: WO2012054332A1Publication Date: 2012-04-26
- Inventor: ENGLAND, Dylan, B. , GIGSTAD, Kenneth, M. , GOULD, Alexandra, E. , MA, Liting , XU, He
- Applicant: MILLENNIUM PHARMACEUTICALS, INC. , ENGLAND, Dylan, B. , GIGSTAD, Kenneth, M. , GOULD, Alexandra, E. , MA, Liting , XU, He
- Applicant Address: 40 Landsdowne Street Cambridge, MA 02139 US
- Assignee: MILLENNIUM PHARMACEUTICALS, INC.,ENGLAND, Dylan, B.,GIGSTAD, Kenneth, M.,GOULD, Alexandra, E.,MA, Liting,XU, He
- Current Assignee: MILLENNIUM PHARMACEUTICALS, INC.,ENGLAND, Dylan, B.,GIGSTAD, Kenneth, M.,GOULD, Alexandra, E.,MA, Liting,XU, He
- Current Assignee Address: 40 Landsdowne Street Cambridge, MA 02139 US
- Agency: GRIFFITHS, Sian, L. et al.
- Priority: US61/393,967 20101018; US61/426,418 20101222
- Main IPC: A61K31/404
- IPC: A61K31/404
Abstract:
This invention provides compounds of formula (I): wherein R 1a , R 1b , R a , R 2a , R 2b , R 1 , and X have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
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