发明申请
WO2012068491A1 PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT WITH ELESCLOMOL BASED ON HYPOXIC STATUS
审中-公开
基于HYPOXIC状态的ELESCLOMOL治疗方案的选择
- 专利标题： PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT WITH ELESCLOMOL BASED ON HYPOXIC STATUS
- 专利标题（中）： 基于HYPOXIC状态的ELESCLOMOL治疗方案的选择
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申请号： PCT/US2011/061453申请日： 2011-11-18
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公开(公告)号： WO2012068491A1公开(公告)日： 2012-05-24
- 发明人: BLACKMAN, Ronald, K. , VUKOVIC, Vojo
- 申请人： SYNTA PHARMACEUTICALS CORP. , BLACKMAN, Ronald, K. , VUKOVIC, Vojo
- 申请人地址： 45 Hartwell Avenue Lexington, MA 02421 US
- 专利权人： SYNTA PHARMACEUTICALS CORP.,BLACKMAN, Ronald, K.,VUKOVIC, Vojo
- 当前专利权人： SYNTA PHARMACEUTICALS CORP.,BLACKMAN, Ronald, K.,VUKOVIC, Vojo
- 当前专利权人地址： 45 Hartwell Avenue Lexington, MA 02421 US
- 代理机构： SPARKS, Jonathan, M. et al.
- 优先权： US61/415,104 20101118
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61P35/00
摘要：
The present invention provides methods for the preselection of a subject for therapeutic treatment with elesclomol based on modulated levels of hypoxia in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic treatment with elesclomol based on modulated levels of lactate dehydrogenase (LDH). The invention also provides methods for treating cancer in a subject by administering an effective amount of elesclomol to the subject, wherein the subject has a modulated level of hypoxia. The invention further provides kits to practice the methods of the invention.
