发明申请
- 专利标题： PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS
- 专利标题（中）： 制备MACROLACTAMS的过程和中间件
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申请号： PCT/US2011064521申请日： 2011-12-13
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公开(公告)号： WO2012082672A3公开(公告)日： 2013-12-27
- 发明人: CHEN CHENG , KONG JONGROCK , HUMPHREY GUY , DOLMAN SARAH , LI HONGMEI , TUDGE MATTHEW T , YONG KELVIN , XIANG BANGPING , ZACUTO MICHAEL
- 申请人： MERCK SHARP & DOHME , CHEN CHENG , KONG JONGROCK , HUMPHREY GUY , DOLMAN SARAH , LI HONGMEI , TUDGE MATTHEW T , YONG KELVIN , XIANG BANGPING , ZACUTO MICHAEL
- 专利权人： MERCK SHARP & DOHME,CHEN CHENG,KONG JONGROCK,HUMPHREY GUY,DOLMAN SARAH,LI HONGMEI,TUDGE MATTHEW T,YONG KELVIN,XIANG BANGPING,ZACUTO MICHAEL
- 当前专利权人： MERCK SHARP & DOHME,CHEN CHENG,KONG JONGROCK,HUMPHREY GUY,DOLMAN SARAH,LI HONGMEI,TUDGE MATTHEW T,YONG KELVIN,XIANG BANGPING,ZACUTO MICHAEL
- 优先权： US42290710 2010-12-14
- 主分类号： A01N43/36
- IPC分类号： A01N43/36 ; A61K31/40
摘要：
The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
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