发明申请
- 专利标题： COMBINATION OF VACCINATION AND INHIBITION OF MHC CLASS I RESTRICTED ANTIGEN PRESENTATION
- 专利标题（中）： MHC类限制性抗原呈递的组合和抑制
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申请号： PCT/EP2010/007969申请日： 2010-12-29
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公开(公告)号： WO2012089225A1公开(公告)日： 2012-07-05
- 发明人: LORENZ, Christina , FOTIN-MLECZEK, Mariola , KALLEN, Karl-Josef
- 申请人： CUREVAC GMBH , LORENZ, Christina , FOTIN-MLECZEK, Mariola , KALLEN, Karl-Josef
- 申请人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 专利权人： CUREVAC GMBH,LORENZ, Christina,FOTIN-MLECZEK, Mariola,KALLEN, Karl-Josef
- 当前专利权人： CUREVAC GMBH,LORENZ, Christina,FOTIN-MLECZEK, Mariola,KALLEN, Karl-Josef
- 当前专利权人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 代理机构： GRAF VON STOSCH, Andreas et al.
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61P35/00 ; A61P31/12
摘要：
The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumour cells and infected cells having lost the capability of MHC class I restricted antigen presentation.
