发明申请
WO2012094386A9 GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS
审中-公开
抗肿瘤抗生素的产生和肿瘤特异性补体的产生依赖于毒蕈碱疫苗病毒的依赖性细胞毒性
- 专利标题： GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS
- 专利标题（中）： 抗肿瘤抗生素的产生和肿瘤特异性补体的产生依赖于毒蕈碱疫苗病毒的依赖性细胞毒性
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申请号： PCT/US2012020173申请日： 2012-01-04
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公开(公告)号： WO2012094386A9公开(公告)日： 2013-08-15
- 发明人: KIRN DAVID , BELL JOHN , BREITBACH CAROLINE , MOON ANNE , HWANG TAE-HO , LEE YU KYOUNG , KIM MI-KYUNG
- 申请人： JENNEREX INC , KIRN DAVID , BELL JOHN , BREITBACH CAROLINE , MOON ANNE , HWANG TAE-HO , LEE YU KYOUNG , KIM MI-KYUNG , SILLAJEN INC
- 专利权人： JENNEREX INC,KIRN DAVID,BELL JOHN,BREITBACH CAROLINE,MOON ANNE,HWANG TAE-HO,LEE YU KYOUNG,KIM MI-KYUNG,SILLAJEN INC
- 当前专利权人： JENNEREX INC,KIRN DAVID,BELL JOHN,BREITBACH CAROLINE,MOON ANNE,HWANG TAE-HO,LEE YU KYOUNG,KIM MI-KYUNG,SILLAJEN INC
- 优先权： US201161429622 2011-01-04
- 主分类号： A61K39/12
- IPC分类号： A61K39/12
摘要：
The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
