Air treatment modules, systems and methods for removing contaminants from indoor air are provided. Device embodiments may include one or more air inlets, one or more air outlets and a plurality of inserts which each include at least one adsorbent material. The inserts may be arranged separate from each other to form a plurality of substantially parallel air flow paths between the one or more air inlets and one or more air outlets. The adsorbent material may be arranged for regeneration within the air treatment module using thermal swing desorption and/or pressure swing desorption. Related systems, methods and articles of manufacture are also described.