Invention Application
- Patent Title: TCR MIMIC ANTIBODIES AS VASCULAR TARGETING TOOLS
- Patent Title (中): TCR MIMIC抗体作为血管造影工具
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Application No.: PCT/US2012/030406Application Date: 2012-03-23
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Publication No.: WO2012129520A1Publication Date: 2012-09-27
- Inventor: WEIDANZ, John A. , BICKEL, Ulrich
- Applicant: TEXAS TECH UNIVERSITY SYSTEM , WEIDANZ, John A. , BICKEL, Ulrich
- Applicant Address: Office of Technology Transfer and Intellectual Prope P.O. Box 42007 Lubbock, Texas 79409-2007 US
- Assignee: TEXAS TECH UNIVERSITY SYSTEM,WEIDANZ, John A.,BICKEL, Ulrich
- Current Assignee: TEXAS TECH UNIVERSITY SYSTEM,WEIDANZ, John A.,BICKEL, Ulrich
- Current Assignee Address: Office of Technology Transfer and Intellectual Prope P.O. Box 42007 Lubbock, Texas 79409-2007 US
- Agency: FLORES, Edwin S.
- Priority: US61/467,215 20110324
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K39/395 ; A61P25/00
Abstract:
The present invention includes a method of delivering a therapeutic agent into and across an endothelial cell (EC) in a subject in need thereof, comprising: attaching to a T Cell receptor mimic (TCR mimic) an active agent to form a therapeutic agent; and administering to the subject the therapeutic agent in a pharmaceutically acceptable carrier, wherein the therapeutic agent effectively crosses the EC microvascular barrier. Furthermore, the present invention relates to methods of treating diseases (particularly neuronal diseases) or conditions comprising identifying a subject in need of such a treatment and administering to said subject a composition comprising a TCR mimic conjugated to an active agent.
Information query
