发明申请
WO2013055177A1 COMPOSITE FORMULATION COMPRISING A TABLET ENCAPSULATED IN A HARD CAPSULE 审中-公开
包含硬化胶囊中的片剂的复合制剂

COMPOSITE FORMULATION COMPRISING A TABLET ENCAPSULATED IN A HARD CAPSULE
摘要:
The present invention relates to a hard capsule composite formulation comprising a capsule having a hemispherical closure at each end and an interior space; and one or more tablets encapsulated in the capsule, wherein the tablet or the tablets as a whole have a shape conforming to the internal space of the capsule. The hard capsule composite formulation can efficiently charge pharmaceutical compositions inside the limited interior space of the capsule, and hence, it allows packing a high-dose of pharmaceutical composition in a relatively small-sized capsule, which increases productivity and patient compliance. Also, the composite formulation exhibits good dissolution rate because pharmaceutically active ingredients contained in the capsule are separated from one another, and thus, the ingredients are less affected by the dissolution rate of one another, allowing good storage stability which can optimize the therapeutic effects.
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