Invention Application
WO2013110680A1 INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING VLA-4
审中-公开
用于定向递送至表达VLA-4的细胞的整合拮抗剂
- Patent Title: INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING VLA-4
- Patent Title (中): 用于定向递送至表达VLA-4的细胞的整合拮抗剂
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Application No.: PCT/EP2013/051275Application Date: 2013-01-24
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Publication No.: WO2013110680A1Publication Date: 2013-08-01
- Inventor: GOODNOW Jr., Robert, Alan , HAMILTON, Matthew, Michael , SIDDURI, Achyutharao
- Applicant: F. HOFFMANN-LA ROCHE AG , GOODNOW Jr., Robert, Alan , HAMILTON, Matthew, Michael , SIDDURI, Achyutharao
- Applicant Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Assignee: F. HOFFMANN-LA ROCHE AG,GOODNOW Jr., Robert, Alan,HAMILTON, Matthew, Michael,SIDDURI, Achyutharao
- Current Assignee: F. HOFFMANN-LA ROCHE AG,GOODNOW Jr., Robert, Alan,HAMILTON, Matthew, Michael,SIDDURI, Achyutharao
- Current Assignee Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Agency: TOWNSEND, Carolin
- Priority: US61/591,295 20120127; US61/670,666 20120712
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61P35/00 ; A61P29/00
Abstract:
The invention relates to compounds of formula I: wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to VLA-4 integrin antagonists to target cells expressing VLA-4.
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