发明申请
WO2013113501A1 PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPIDE ANTIGEN
审中-公开
包含聚合物载体复合物和至少一种蛋白质或抗原抗原的药物组合物
- 专利标题： PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPIDE ANTIGEN
- 专利标题（中）： 包含聚合物载体复合物和至少一种蛋白质或抗原抗原的药物组合物
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申请号： PCT/EP2013/000291申请日： 2013-01-31
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公开(公告)号： WO2013113501A1公开(公告)日： 2013-08-08
- 发明人: BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
- 申请人： CUREVAC GMBH , BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
- 申请人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 专利权人： CUREVAC GMBH,BAUMHOF, Patrick,KRAMPS, Thomas,VOSS, Söhnke,KALLEN, Karl-Josef,FOTIN-MLECZEK, Mariola
- 当前专利权人： CUREVAC GMBH,BAUMHOF, Patrick,KRAMPS, Thomas,VOSS, Söhnke,KALLEN, Karl-Josef,FOTIN-MLECZEK, Mariola
- 当前专利权人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 代理机构： GRAF VON STOSCH, Andreas et al.
- 优先权： EPPCT/EP2012/000420 20120131
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K39/39 ; A61P35/00 ; A61P37/00 ; A61P31/00
摘要：
The present invention is directed to a pharmaceutical composition including (e.g. for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease; an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits, as well as the use of the pharmaceutical composition or the kit as a vaccine, particularly in the treatment of infectious diseases, allergies, autoimmune diseases and tumour or cancer diseases.
