Embodiments of processors, methods, and systems for directed wakeup into a secured system environment are disclosed. In one embodiment, a processor includes a decode unit, a control unit, and a messaging unit. The decode unit is to receive a secured system environment wakeup instruction. The control unit is to cause wake-inhibit indicator to be set for each of a plurality of responding logical processor to be kept in a sleep state. The messaging unit is to send a wakeup message to the plurality of responding logical processors, wherein the wakeup message is to be ignored by each of the plurality of responding logical processors for which the wake-inhibit indicator is set.