Invention Application
- Patent Title: APOPTOSIS BIOMARKERS
- Patent Title (中): 杀虫剂生物标志物
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Application No.: PCT/US2013/046554Application Date: 2013-06-19
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Publication No.: WO2013192298A1Publication Date: 2013-12-27
- Inventor: DIX, Melissa , SIMON, Gabriel, M. , CRAVATT, Benjamin, F.
- Applicant: THE SCRIPPS RESEARCH INSTITUTE , DIX, Melissa , SIMON, Gabriel, M. , CRAVATT, Benjamin, F.
- Applicant Address: 10550 North Torrey Pines Road La Jolla, CA 92037 US
- Assignee: THE SCRIPPS RESEARCH INSTITUTE,DIX, Melissa,SIMON, Gabriel, M.,CRAVATT, Benjamin, F.
- Current Assignee: THE SCRIPPS RESEARCH INSTITUTE,DIX, Melissa,SIMON, Gabriel, M.,CRAVATT, Benjamin, F.
- Current Assignee Address: 10550 North Torrey Pines Road La Jolla, CA 92037 US
- Agency: FITTING, Thomas et al.
- Priority: US61/663,076 20120622
- Main IPC: C07K7/08
- IPC: C07K7/08 ; G01N33/68
Abstract:
The present invention provides novel biomarkers for apoptosis. The apoptosis biomarkers comprise a polypeptide with a caspase cleaved terminus and also a phosphotylaCed amino acid residue located close to the terminus (e.g., within about 15 residues). The invention also provides methods of using such biomarkers to monitor apoptotic activities and methods for identifying apoptosis biomarkers in various cellular systems.
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