Apparatus and methods are provided for delivering fluid into a body lumen. The apparatus may include a catheter including proximal and distal ends, a fluid delivery lumen extending from the proximal end to a transit port on a distal portion of the catheter, and an inflatable infusion element on the distal portion such that an interior of the inflatable infusion element communicates with the fluid delivery lumen. During use, a distal end of the catheter is introduced into a lumen or conduit with the inflatable infusion element in a collapsed condition, the inflatable infusion element is expanded to an expanded condition to partially or totally occlude the lumen or conduit, and fluid is infused from the catheter into the lumen or conduit proximally relative to the inflatable infusion element while the inflatable infusion element remains in the expanded condition.