Artificial aspiration methods and systems for increasing engine efficiency and or power. The methods include determining an engine operation status, determining an artificial aspiration goal value based on the engine operating status, determining an artificial aspiration system configuration based on the artificial aspiration goal value and the engine operating status, and configuring the artificial aspiration system to obtain the determined artificial aspiration system configuration. The system includes a plurality of sensors for sensing characteristics of an operating engine, and an artificial aspiration control unit comprising a processor connected to receive the sensed characteristics of the engine. On one example, the processor is configured to determine the engine operating status, determine an artificial aspiration goal value based on the engine operating status, determine an artificial aspiration system configuration based on the artificial aspiration goal value and the engine operating status, and configure the artificial aspiration system to obtain the determined artificial aspiration system configuration.