发明申请
WO2014093712A9 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
审中-公开
系统的工程，方法和优化的指导组合序列操作
- 专利标题： ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
- 专利标题（中）： 系统的工程，方法和优化的指导组合序列操作
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申请号： PCT/US2013074819申请日： 2013-12-12
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公开(公告)号： WO2014093712A9公开(公告)日： 2014-08-21
- 发明人: ZHANG FENG , CONG LE , HSU PATRICK , RAN FEI
- 申请人： BROAD INST INC , MASSACHUSETTS INST TECHNOLOGY , HARVARD COLLEGE , ZHANG FENG , CONG LE , HSU PATRICK , RAN FEI
- 专利权人： BROAD INST INC,MASSACHUSETTS INST TECHNOLOGY,HARVARD COLLEGE,ZHANG FENG,CONG LE,HSU PATRICK,RAN FEI
- 当前专利权人： BROAD INST INC,MASSACHUSETTS INST TECHNOLOGY,HARVARD COLLEGE,ZHANG FENG,CONG LE,HSU PATRICK,RAN FEI
- 优先权： US201361769046 2013-02-25; US201361791409 2013-03-15; US201361802174 2013-03-15; US201361806375 2013-03-28; US201361814263 2013-04-20; US201361819803 2013-05-06; US201361828130 2013-05-28; US201361835931 2013-06-17; US201361836127 2013-06-17; US201261736527 2012-12-12; US201361748427 2013-01-02; US201361758468 2013-01-30
- 主分类号： C12N15/63
- IPC分类号： C12N15/63
摘要：
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system.
IPC分类:
